|
KMID : 0385020030190010017
|
|
Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 1 p.17 ~ p.23
|
|
|
High Resolution Transcript map of the D14MTt86 Vegron Linked to the Cataract Causing Gene Ir2
|
|
김은민/Kim, Eunmin
이상달/이형남/양승돈/MasaakiOkumoto/송창우/김성주/Rhee, Sang Dal/Lee, Hyoungnam/Yang,Sung-Don/Masaaki, Okumoto/Song, Chang-Woo/Kim, Sung-joo
|
|
|
Abstract
|
|
|
|
A recessive cataractous mouse, CXSD, showed the first clinical symptom of cataract at 5 weeks old and the penetrance was complete. Toward the identification of lens rupture 2 (lr2)gene causing cataract by positional cloning, we constructed an sequence tagged site (STS)-content map of the region around D14Mit86 that was shown to be linked to lr2 genetically. We determined the physical order of 29 STSs that were dispersed among 4 YAC clones and 40 BAC clones. The markers included 5 genetic, 18 cloneend, 6 gene specific EST markers. The genes include Adam 7, Decysin, Adam28, Stc, Nkx3-1 and LAP70 and Nkx3-1 was known to map to the human chromosome 8p21. Therefore, this map represents the part of mouse genome synteny to that of the human genome. The current map would provide groundwork for identification of lr-2 gene.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|